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These mechanisms raise a theoretical concern: could supratherapeutic doses accelerate unwanted vascular growth or disrupt dopamine signaling enough to produce neuropsychiatric symptoms
The higher the dose, the higher the risk of issues
The quartile approach to define poor performance emphasizes patient safety globally
It affects ~5% of the population worldwide (Box 1 ( Box 1 Symptoms of MDD: as per diagnostic and statistical manual of mental disorder (DSM-V) at least five of the following symptoms must be present during entire 2-week period (5bibrB5)
The optimal administration time is typically right before bed, on an empty stomach (at least 90 minutes after the last meal)
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